POST-GENOME ANALYSIS FOR MUSCULOSKELETAL BIOLOGY
Workshop: “Post-Genome analysis for musculoskeletal biology”
סדנה בנושא ביולוגיה של שריר ושלד בעידן הפוסט גנומי
Venue: Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Galilee, Israel
Dates: 27-29 July, 2022
Organized by Prof. David Karasik, Ph.D. and Chen Shochat-Carvalho, Ph.D.
Musculoskeletal Genetics Laboratory
Azrieli Faculty of Medicine, Bar-Ilan University
H. Szold st. 14, POB 1589 Safed 1311502, Israel
Tel: 072-2644958
Email: david.karasik@biu.ac.il
Background
In the framework of the project funded by the Israel Science Foundation (ISF) (#1283/14) we introduced zebrafish as a model to validate musculoskeletal genome-wide association studies. This workshop – funded by the ISF - aims to provide a platform for –omic-centered researchers from Israel and abroad to facilitate crosstalk, establish collaboration, and validate new experimental models of musculoskeletal health. A variety of world-renown speakers will provide their insights into the current and future work on the fast-growing field of the post-genomic exploration.
We have two main objectives for the planned symposium:
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Acquire a better understanding of advantages and challenges in using the functional approaches for the bone biology in piscine and rodent models, and ultimately human cells. Specific focus is on latest advancement in imaging modalities, genetic methodologies, and nano-technology approaches.
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Learn about the current state of knowledge and ongoing research activities in the musculoskeletal diseases, such as osteosarcopenia, falls and fracture.
We hope to translate the findings of this research into novel therapeutic strategies effective for the musculoskeletal system, for preventing and treating fractures and muscle loss by targeting actionable genes.
OUR SCHEDULE
Day 1 - Wed., July 27th
Genetics of Osteosarcopenia and Diseases of Musculoskeletal Aging
Day 2 - Thur., July 28th
Animal modelling in aging genetic disease
Venue: Hotel Ruth Zefat, Gefen Hall
(for address & parking info, pls. see the map below)
10:30
Check-in, Coffee
11:30
Welcome by the organizers (David Karasik)
11:45
Welcome note: Chaim Putterman, MD, Vice Dean for Research (BIU)
12:00
Keynote lecture I: Yi-Hsiang Hsu (Harvard, Boston, USA): “From GWAS to Function: Integrating multi-omics approaches to dissect and exploit disease-associated genetic variation and target genes of bone and muscle mass"
13:00
Oral Presentations – Session I – G. Atzmon (Haifa U.) “GWAS of the human mobility”
13:30
Lunch break
Oral Presentations – Session I – Alon Barash (BIU) on "Evolution of Muscle & Bone"
14:00
15:00
Oral Presentations – GWAS in MSK biological research:
Gregory Livshits (TAU) “Multiomics of lean body mass with FTO-gene effects revisited”
Ramon Birnbaum (BGU/Beer Sheva): "Coding and non-coding mutations in craniosynostosis"
16:30
Coffee break
17:00
Keynote lecture II: Gustavo Duque, MD (Australia): “Osteosarcopenia: diagnosis and pathogenesis”
18:00
Oral Presentations – Session II – Diseases of musculoskeletal aging: David Karasik on "Aging in Fish"
18:30
Symposium Dinner (hotel Ruth)
Venue: Faculty of Medicine
(pls. use "Bezek" parking lot marked in the map below)
09:30
Lecture: Lihi Adler-Abramovich (TAU) on "Designing New Bioinspired 3D-Hydrogels for Bone-Tissue Regeneration"
10:15
Oral Presentations – Session III – From GWAS to NGS to RNAs to proteins - Prof. Livshits’ lab
Keynote Lecture III: Yankel Gabet (TAU) on “OGP, a new endogenous selective CB2 agonist with implications in musculoskeletal diseases”
11:00
11:45
Oral Presentations – Musculoskeletal disease: fish models - Prof. Karasik’s lab
12:45
Lunch break
Keynote Lecture IV: Itamar Harel (Hebrew U., Jerusalem) on "Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis"
13:30
14:30
Lecture: Cheryl Ackert-Bicknell (Colorado, USA) “Using Skull BMD to understand the osteoblast function in bone biology”
15:00
Oral Presentations – Session IV: Models of musculoskeletal development
Chaya Brodie (BIU): "Studying the role of extracellular vesicles in human and mouse models of Duchenne Muscular Dystrophy"
16:00
Coffee break
16:20
Oral Presentations IV: Genetic engineering in model fish – Itamar Harel on "Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate"
16:45
Rajashekar Donaka (Karasik lab)
17:10
Lecture: Yaniv Giman (Daniel biotech) on "Single Cell & Spatial transcriptomics – Advance Approaches in Genomic"
17:45
Panel discussion
Free evening
Day 3 - Fri., July 29th
Day of the Bone Biology
Venue: Faculty of Medicine
10:00
Tour of the Faculty of Medicine (David Karasik)
10:30
Keynote lecture V: Cheryl Ackert-Bicknell (Colorado, USA) “Pleiotropy of Bone-Associated GWAS loci”
11:30
Oral Presentations – Session V: Musculoskeletal disease models
Mona Dvir-Ginzberg (HUJ): "Mitigating Osteoarthritis by Cannabinoid-Inspired Compounds"
David Karasik: Muscles of Fish.
12:30
Lunch break
13:30
Keynote Lecture VI: Yuuki Imai (Japan) “Identification of novel therapeutic targets for musculoskeletal diseases using integrative genome-wide analyses”
14:15
Lecture: Noam Levaot (Beer Sheba, IS) on "Harnessing protein-protein interactions to make stronger bones”
15:00
Lecture: Inga Peter (Mt Sinai, NY, USA) on "GWAS & WGS of craniosynostosis with a focus on fish modeling”
16:00
Departure – majority of the participants
Day 4 - Sat., July 30th
09:00
Breakfast
10:00
Tour in the Kibbutz Ayelet HaShahar (foreign guests)
13:00
Lunch in Hula
15:00
Departure (to Tel Aviv)
SPONSORS
